SKIN REGENERATION

SKIN STRUCTURE

In humans, the skin has three parts - the epidermis, the dermis and the subcutis (or hypodermis). The epidermis forms the surface of the skin. It is made up of several layers of cells called keratinocytes. The dermis lies underneath the epidermis and contains skin appendages: hair follicles, sebaceous glands and sweat glands. The subcutis contains fat cells and some sweat glands.

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SKIN IN CULTURE

Three types of clonogenic keratinocytes endowed with different capacity for multiplication have been identified in human squamous epithelia and are referred to as holoclones, meroclones and paraclones. Holoclones are generated by stem cells, whilst meroclones and paraclones have properties of transit amplifying progenitors.

Epithelial cultures containing holoclone-forming cells are now widely used in Regenerative Medicine.

Humvira is devoted to development, manufacture, registration and distribution of advanced therapies medicinal products based on cultures of epithelial stem cells.

SKIN MANUFACTURER

The GMP facility has multi-independent BL2 rooms fully equipped for cell culture, quality controls and common culture media and reagent preparation.
The GMP facility contains also a machinery for automated quantitative immunohistochemistry and in situ hybridization, terminals for control and monitoring system  and is equipped for histology, immunofluorescence and X-ray cell irradiation.
The top floor has  beyond other equipments, 15 HVAC (High Volume Air Conditioner) to feed sterile air to cell culture rooms, vacuum generation and distribution line, a central unit for production and distribution of purified water (according to EU Pharmacopoeia), an UPS (Uninterruptible Power Supply).
Planned maintenance and calibration are regularly applied to every equipment and process.